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Clinical trials that are designed to help inform practice in the real world are known as pragmatic trials. They are typically described as a focus on the practical aspects of study design that include the recruitment process and consent, adhering and the use of routinely available equipment.

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A pragmatic study that involves a variety investigators and includes participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity which is vital for pragmatic trials to be valid and lessen the chance of bias, is also necessary. A high degree of heterogeneity, however can result in problems with the trial design.

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Pragmatic trials aim to mimic real-world situations and have the highest external validity. They are typically ordered by policymakers and practitioners to inform their decisions. They can also be used to determine the cause-effect relationship of an intervention with its outcomes. They should not, however, be used to replace the need for explanation studies.

The concept of pragmatism is controversial and there are doubts about whether pragmatic trials should replace tests for 프라그마틱 불법 explanations or if they should be an addition to them. Schwartz and Lellouch1 made an distinction between explanation-based studies, which prove a physiological hypothesis or clinical hypothesis, as well as pragmatic trials, that inform the practice and policy decision-making. They also proposed a framework called PRECIS for pragmatic trials.2 This tool tried to define the elements of a pragmatic study that includes the recruitment, design, and delivery of the intervention and follow-up.

There is a growing trend in the number of pragmatic trials published. A recent Medline search using the keywords naturalistic and pragmatic, which was limited to controlled trials that are randomized (RCTs) produced 34 articles, as shown in red in Figure 2. This is a sign that the health science community is becoming more acquaint to the issue of pragmatic thinking. It is important to keep in mind, however, that the majority of studies were conducted in primary-care settings.